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Lancet 2021;398:216072.ArticlePubMed 100

Phase 2 failed primary endpoint Attribute Unique advantage SLU-PP-332 Only pan-ERR agonist with demonstrated in-vivo exercise-mimetic activity MOTS-c Endogenous mitochondrial peptide with AMPK-focused signaling AOD-9604 Most human clinical history of the three Half-life and dose figures across the three compounds are mostly from animal data and should not be read as validated human pharmacology

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Historically, the obesity pharmacotherapy literature notes early trial signals and also that development was terminated after failure to show meaningful weight loss in a larger, longer trial (as summarized in a peer-reviewed review discussing a 12-week signal and a later 24-week negative result)

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